Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
S Carvalho, AC Vítor, SC Sridhara, FB Martins… - elife, 2014 - elifesciences.org
Histone modifications establish the chromatin states that coordinate the DNA damage
response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 …
response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 …
Greater than the sum of parts: complexity of the dynamic epigenome
AA Soshnev, SZ Josefowicz, CD Allis - Molecular cell, 2016 - cell.com
Information encoded in DNA is interpreted, modified, and propagated as chromatin. The
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …
Regulation of neuronal differentiation, function, and plasticity by alternative splicing
E Furlanis, P Scheiffele - Annual review of cell and …, 2018 - annualreviews.org
Posttranscriptional mechanisms provide powerful means to expand the coding power of
genomes. In nervous systems, alternative splicing has emerged as a fundamental …
genomes. In nervous systems, alternative splicing has emerged as a fundamental …
Introns protect eukaryotic genomes from transcription-associated genetic instability
A Bonnet, AR Grosso, A Elkaoutari, E Coleno, A Presle… - Molecular cell, 2017 - cell.com
Transcription is a source of genetic instability that can notably result from the formation of
genotoxic DNA: RNA hybrids, or R-loops, between the nascent mRNA and its template. Here …
genotoxic DNA: RNA hybrids, or R-loops, between the nascent mRNA and its template. Here …
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic
transcription is first detected shortly after pronucleus formation in 1‐cell embryos, but the …
transcription is first detected shortly after pronucleus formation in 1‐cell embryos, but the …
The features and regulation of co-transcriptional splicing in Arabidopsis
Precursor mRNA (pre-mRNA) splicing is essential for gene expression in most eukaryotic
organisms. Previous studies from mammals, Drosophila, and yeast show that the majority of …
organisms. Previous studies from mammals, Drosophila, and yeast show that the majority of …
Exonic splice regulation imposes strong selection at synonymous sites
R Savisaar, LD Hurst - Genome research, 2018 - genome.cshlp.org
What proportion of coding sequence nucleotides have roles in splicing, and how strong is
the selection that maintains them? Despite a large body of research into exonic splice …
the selection that maintains them? Despite a large body of research into exonic splice …
Regulation of alternative splicing by p300-mediated acetylation of splicing factors
Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression.
Recent evidence points to a regulatory role of chromatin-related proteins in alternative …
Recent evidence points to a regulatory role of chromatin-related proteins in alternative …