Microelimination of chronic hepatitis C by universal screening plus direct-acting antivirals for incarcerated persons in Taiwan

TH Yang, YJ Fang, SJ Hsu, JY Lee… - Open Forum …, 2020 - academic.oup.com
Background Incarcerated persons are a special population with higher hepatitis C virus
(HCV) prevalence and should be prioritized for microelimination. In this study, we investigate …

Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies

MR Walker, P Leung, AA Eltahla, A Underwood… - Scientific reports, 2019 - nature.com
Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or
alternatively persist to cause chronic disease. Viral diversity and escape, as well as host …

Envelope-specific IgG3 and IgG1 responses are associated with clearance of acute hepatitis C virus infection

MR Walker, AA Eltahla, MM Mina, H Li, AR Lloyd… - Viruses, 2020 - mdpi.com
Hepatitis C virus (HCV) can be cleared naturally in a subset of individuals. However, the
asymptomatic nature of acute HCV infection makes the study of the early immune response …

A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease

C Young, M Singh, KJL Jackson, MA Field, TJ Peters… - Immunity, 2025 - cell.com
The unexplained association between infection and autoimmune disease is strongest for
hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins …

[HTML][HTML] B cell characteristics define HCV reinfection outcome

AP Underwood, M Gupta, BR Wu, AA Eltahla, I Boo… - Journal of …, 2024 - Elsevier
Background and aims In individuals highly exposed to hepatitis C virus (HCV), reinfection is
common, suggesting that natural development of sterilising immunity is difficult. In those that …

Understanding the determinants of BnAb induction in acute HCV infection

AP Underwood, MR Walker, NA Brasher, AA Eltahla… - Viruses, 2018 - mdpi.com
Despite recent advances in curative therapy, hepatitis C virus (HCV) still remains a global
threat. In order to achieve global elimination, a prophylactic vaccine should be considered …

Injecting drug use and hepatitis C virus infection independently increase biomarkers of inflammatory disease risk which are incompletely restored by curative direct …

AC Hearps, N Vootukuru… - Frontiers in …, 2024 - frontiersin.org
Background Hepatitis C virus (HCV) infections are more prevalent in people who inject
drugs (PWID) who often experience additional health risks. HCV induces inflammation and …

A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers

BR Wu, AA Eltahla, E Keoshkerian, MR Walker… - Journal of …, 2019 - Elsevier
Hepatitis C (HCV) is a rapidly mutating RNA virus, with a strong propensity to cause chronic
infection and progressive liver disease. Recent evidence has shown that early appearance …

Characterization of antibody‐dependent cellular phagocytosis in patients infected with hepatitis C virus with different clinical outcomes

A Adhikari, A Abayasingam, NA Brasher… - Journal of Medical …, 2024 - Wiley Online Library
Early neutralizing antibodies against hepatitis C virus (HCV) and CD8+ T cell effector
responses can lead to viral clearance. However, these functions alone are not sufficient to …

Optimisation and validation of a new method for antibody dependent cellular phagocytosis in hepatitis C virus infection

A Adhikari, A Eltahla, AR Lloyd, C Rodrigo… - Journal of …, 2021 - Elsevier
Lack of a simple, high throughput antibody-dependent cellular phagocytosis (ADCP) assay
has limited our understanding of its potential role of in hepatitis C (HCV) infection. Here, we …