Circadian dysfunction in adipose tissue: chronotherapy in metabolic diseases

E Civelek, D Ozturk Civelek, YK Akyel, D Kaleli Durman… - Biology, 2023 - mdpi.com
Simple Summary The circadian timing system is our bodies' built-in clock and controls our
physiology on a daily basis. This system helps us adapt to changes in our environment, such …

The intersection between ghrelin, metabolism and circadian rhythms

SS Kulkarni, O Singh, JM Zigman - Nature Reviews Endocrinology, 2024 - nature.com
Despite the growing popular interest in sleep and diet, many gaps exist in our scientific
understanding of the interaction between circadian rhythms and metabolism. In this Review …

Brain dopamine–clock interactions regulate cardiometabolic physiology: mechanisms of the observed cardioprotective effects of circadian-timed bromocriptine-QR …

AH Cincotta - International Journal of Molecular Sciences, 2023 - mdpi.com
Despite enormous global efforts within clinical research and medical practice to reduce
cardiovascular disease (s)(CVD), it still remains the leading cause of death worldwide. While …

Therapeutic potential of dopamine and related drugs as anti-inflammatories and antioxidants in neuronal and non-neuronal pathologies

C Bandala, N Cárdenas-Rodríguez… - Pharmaceutics, 2023 - mdpi.com
Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the
management of diseases related to the nervous system. However, DA receptors have been …

Bromocriptine-QR therapy reduces sympathetic tone and ameliorates a pro-oxidative/pro-inflammatory phenotype in peripheral blood mononuclear cells and plasma …

AH Cincotta, E Cersosimo, M Alatrach… - International journal of …, 2022 - mdpi.com
Bromocriptine-QR is a sympatholytic dopamine D2 agonist for the treatment of type 2
diabetes that has demonstrated rapid (within 1 year) substantial reductions in adverse …

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

AN Vaganova, TS Shemyakova, KV Lenskaia… - Biomolecules, 2023 - mdpi.com
Currently, metabolic syndrome treatment includes predominantly pharmacological symptom
relief and complex lifestyle changes. Trace amines and their receptor systems modulate …

Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review

AG Golubev - Ageing Research Reviews, 2022 - Elsevier
Macromolecules damaged by covalent modifications produced by chemically reactive
metabolites accumulate in the slowly renewable components of living bodies and …

Dopamine D1 receptor-mediated regulation of Per1, Per2, CLOCK, and BMAL1 expression in the suprachiasmatic nucleus in adult male rats

S Mesgar, SB Jameie, A Aliaghaei, S Parvardeh… - Journal of Molecular …, 2022 - Springer
Photic and non-photic inputs are reported to affect clock gene expressions and behavioral
activities in the SCN. However, it is not known whether dopaminergic input mediates these …

Circadian desynchrony and glucose metabolism

EM Speksnijder, PH Bisschop… - Journal of pineal …, 2024 - Wiley Online Library
The circadian timing system controls glucose metabolism in a time‐of‐day dependent
manner. In mammals, the circadian timing system consists of the main central clock in the …

Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

P Senesi, A Ferrulli, L Luzi, I Terruzzi - Frontiers in endocrinology, 2022 - frontiersin.org
Circadian rhythm, an innate 24-h biological clock, regulates several mammalian
physiological activities anticipating daily environmental variations and optimizing available …