1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

The hydrofluorination of alkynes is an efficient synthetic route to monofluoroalkenes or
difluoroalkanes. Both fluorinated motifs have found applications in medicinal chemistry and …

Biomass is a renewable source of valuable feedstock for the chemical industry of the future.
A promising approach to the utilization of valuable components of biomass is the synthesis …

The discovery of safe, general, and practical procedures to prepare vinyl fluorides from
readily available precursors remains a synthetic challenge. The metal‐free hydrofluorination …

We report the palladium‐catalyzed gem‐difluoroallylation of aryl halides and pseudo
halides with 3, 3‐difluoroallyl boronates in high yield with high regioselectivity, and we …

Electrophilic addition reaction to alkynes is of fundamental importance in organic chemistry,
yet the regiocontrol when reacting with unsymmetrical 1, 2‐dialkyl substituted alkynes is …

Fluorinated organic molecules have found numerous applications in medicinal chemistry, as
the incorporation of fluorine often improve metabolic stability, lipophilicity and bioactivity …

Harnessing the acidity of HF/base reagents is of paramount importance to improve the
efficiency and selectivity of fluorination reactions. Yet, no general method has been reported …

Abstract gem-Difluorination of carbon–carbon triple bonds was conducted using Brønsted
acids, such as Tf 2 NH and TfOH, combined with Bu 4 NBF 4 as the fluorine source. The …

The hydrofluorination of enynoates has been developed for the synthesis of fluorinated
dienoates. Using a pyridinium tetrafluoroborate salt that is easily prepared on large scale …