Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

An essential property of the plasma membrane of mammalian cells is its plasticity, which is
required for sensing and transmitting of signals, and for accommodating the tensional …

Current asthma therapies fail to target airway remodeling that correlates with asthma
severity driving disease progression that ultimately leads to loss of lung function …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Asthma is characterized by airway inflammation, mucus secretion, remodeling and
hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of …

HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is
inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects …

Geranylgeranyl transferase 1 (GGT1) is involved in the posttranslational prenylation of
signaling proteins, such as small GTPases. We have shown that blocking the formation of …

Edema is a hallmark of many brain disorders including stroke. During vasogenic edema,
blood-brain barrier (BBB) permeability increases, contributing to the entry of plasma proteins …

Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G
protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq …