Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

Cancer predisposition syndromes are recognized in about 10% of pediatric malignancies
with several genes specifically involved in a subset of pediatric tumors such as DICER1, in …

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex
joined to a displaced strand of genomic DNA. While the effects of R-loops on health and …

Unscheduled R-loops usually cause DNA damage and replication stress, and are therefore
a major threat to genome stability. Several RNA processing factors, including the conserved …

Recently, there has been increasing interest in the complex relationship between
transcription and genome stability, with specific attention directed toward the physiological …

The human let-7 miRNA family consists of thirteen members that play critical roles in many
biological processes, including development timing and tumor suppression, and their levels …

R-loops, composed of DNA–RNA hybrids and displaced single-stranded DNA, are known to
pose a severe threat to genome integrity. Therefore, extensive research has focused on …

DNA replication often encounters obstacles like the stalled transcription machinery and R-
loops. While ribonucleases and DNA-RNA helicases can resolve these structures, the role of …

摘要背景: 课题组前期研究发现, 增生性瘢痕特异性长链非编码RNA HSFAS
是一种可用于增生性瘢痕诊断的新型生物标志物, 但其如何在增生性瘢痕中发挥作用尚不清楚 …