Depression and obesity: evidence of shared biological mechanisms

Y Milaneschi, WK Simmons, EFC van Rossum… - Molecular …, 2019 - nature.com
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Bipolar disorders

E Vieta, M Berk, TG Schulze, AF Carvalho… - Nature reviews Disease …, 2018 - nature.com
Bipolar disorders are chronic and recurrent disorders that affect> 1% of the global
population. Bipolar disorders are leading causes of disability in young people as they can …

Rare coding variants in ten genes confer substantial risk for schizophrenia

T Singh, T Poterba, D Curtis, H Akil, M Al Eissa… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

BW Kunkle, B Grenier-Boley, R Sims, JC Bis… - Nature …, 2019 - nature.com
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

What causes psychosis? An umbrella review of risk and protective factors

J Radua, V Ramella‐Cravaro, JPA Ioannidis… - World …, 2018 - Wiley Online Library
Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and
protective factors have been suggested. This umbrella review aimed to classify the strength …

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

DR Goldsmith, MH Rapaport, BJ Miller - Molecular psychiatry, 2016 - nature.com
Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been
associated with aberrant blood cytokine levels; however, neither the pattern of cytokine …

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

RS Duman, GK Aghajanian, G Sanacora, JH Krystal - Nature medicine, 2016 - nature.com
Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …