Background: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain
fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) …

Oxidative stress, manifested by protein oxidation, lipid peroxidation, DNA oxidation and 3-
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …

Amyloid fibrils formed from different proteins, each associated with a particular disease,
contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming …

In recent years, small protein oligomers have been implicated in the aetiology of a number of
important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's …

We describe solid-state nuclear magnetic resonance (NMR) measurements on fibrils formed
by the 40-residue β-amyloid peptide associated with Alzheimer's disease (Aβ1-40) that …

The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …

Alzheimer's disease (AD) is a complex age‐related neurodegenerative disease. In this
review, we carefully detail amyloid‐β metabolism and its role in AD. We also consider the …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing
population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

Pioneering work in the 1950s by Christian Anfinsen on the folding of ribonuclease has
shown that the primary structure of a protein “encodes” all of the information necessary for a …