Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …

Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis
imperfecta. However, the mechanisms controlling bone quality are not well understood …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment
outcome is evaluated based mainly on routine clinical outcomes of bone mineral density …

The effects of subclinical hypocalcemia have been explored in numerous observational and
mechanistic studies in recent years. Besides obvious, well-known effects on muscle …

Osteocytes, the most abundant bone cell in the adult skeleton, can function as
mechanosensors directing osteoblast and osteoclast function in order to maintain optimal …

Osteoporosis is an aging-related disease of reduced bone mass that is particularly prevalent
in post-menopausal women, but also affects the aged male population and is associated …

Bone is an architecturally complex system that constantly undergoes structural and
functional optimisation through renewal and repair. The scanning electron microscope …