Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …

Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Background The emergence of artemisinin-resistant Plasmodium falciparum strains poses a
serious challenge to the control of malaria. This necessitates the development of new anti …

SUMMARY Heat shock protein 90 (Hsp90) participates in proteostasis by facilitating protein
folding, activation, disaggregation, prevention of aggregation, degradation, and protection …

Abstract Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during
stress or non-stress responses. Previous reports have shown that Hsp90 is a potential drug …

The high sequence conservation of druggable pockets of closely related proteins can make
it challenging to develop selective inhibitors. We designed a new drug discovery approach …

Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The
current drugs available to eliminate the causative agent Trypanosoma brucei have multiple …

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects over 6
million people worldwide. Development of new drugs to treat this disease remains a priority …

Human African trypanosomiasis (HAT), also known as African sleeping sickness, is caused
by parasitic protozoa of the genus Trypanosoma. As the disease progresses, the parasites …