The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Cancer cells are characterized by altered glucose metabolism known as the Warburg effect
in which aerobic glycolysis is increased. Glucose is converted to lactate even under …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …

Auranofin is an oral gold (I) compound, initially developed for the treatment of rheumatoid
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …

Purpose Cancer, a major public health problem, exhibits significant redox alteration.
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …

Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for
many chemotherapeutics, while resettled redox homeostasis induced by the anticancer …

Chronic lymphocytic leukemia (CLL) exhibits high remission rates after initial
chemoimmunotherapy, but with relapses with treatment, refractory disease is the most …