Neural signalling of gut mechanosensation in ingestive and digestive processes
Eating and drinking generate sequential mechanosensory signals along the digestive tract.
These signals are communicated to the brain for the timely initiation and regulation of …
These signals are communicated to the brain for the timely initiation and regulation of …
Acid-sensitive ion channels and receptors
P Holzer - Sensory nerves, 2009 - Springer
Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …
containment. As a consequence, acid sensing has evolved as an important property of …
Selective role for TRPV4 ion channels in visceral sensory pathways
Background & Aims: Although there are many candidates as molecular
mechanotransducers, so far there has been no evidence for molecular specialization of …
mechanotransducers, so far there has been no evidence for molecular specialization of …
Spinal afferent innervation of the colon and rectum
Despite their seemingly elementary roles, the colon and rectum undertake a variety of key
processes to ensure our overall wellbeing. Such processes are coordinated by the …
processes to ensure our overall wellbeing. Such processes are coordinated by the …
ENaC structure and function in the wake of a resolved structure of a family member
OB Kashlan, TR Kleyman - American Journal of Physiology …, 2011 - journals.physiology.org
Our understanding of epithelial Na+ channel (ENaC) structure and function has been
profoundly impacted by the resolved structure of the homologous acid-sensing ion channel …
profoundly impacted by the resolved structure of the homologous acid-sensing ion channel …
[HTML][HTML] ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury
RY Walder, LA Rasmussen, JD Rainier, AR Light… - The Journal of pain, 2010 - Elsevier
Acid-sensing ion channels (ASICs) respond to acidosis that normally occurs after
inflammation. We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar …
inflammation. We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar …
Diet‐induced adaptation of vagal afferent function
Non‐technical summary Obesity is the result of a disruption in the maintenance of energy
balance such that energy intake exceeds expenditure. Why this occurs is unknown. We …
balance such that energy intake exceeds expenditure. Why this occurs is unknown. We …
Genetic exploration of the role of acid-sensing ion channels
Advanced gene targeting technology and related tools in mice have been incorporated into
studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out …
studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out …
Visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents
Background Although development of visceral pain is an important defensive mechanism,
hypersensitivity results in a significant clinical problem and is likely to be one of the major …
hypersensitivity results in a significant clinical problem and is likely to be one of the major …
Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells
J Tong, WN Wu, X Kong, PF Wu, L Tian… - The Journal of …, 2011 - journals.aai.org
As an H+-gated subgroup of the degenerin/epithelial Na+ channel family, acid-sensing ion
channels (ASICs) were reported to be involved in various physiological and pathological …
channels (ASICs) were reported to be involved in various physiological and pathological …