Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Timing and duration of sleep are controlled by the circadian system, which keeps an~ 24-h
internal rhythm that entrains to environmental stimuli, and the sleep homeostat, which rises …

Most organisms possess time-keeping devices called circadian clocks. At the molecular
level, circadian clocks consist of transcription–translation feedback loops (TTFLs). Although …

Circadian rhythms, present in most phyla across life, are biological oscillations occurring on
a daily cycle. Since the discovery of their molecular foundations in model organisms, many …

Nearly all mammals display robust daily rhythms of physiology and behavior. These
approximately 24-h cycles, known as circadian rhythms, are driven by a master clock in the …

Nearly all living organisms, from cyanobacteria to humans, have an internal circadian
oscillation with a periodicity of approximately 24 h. In mammals, circadian rhythms regulate …

The regulation of neurons by circadian clock genes is thought to contribute to the
maintenance of neuronal functions that ultimately underlie animal behavior. However, the …

Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep
significantly shorter than the average population without a desire for more sleep and without …

TIMELESS (TIM) was first identified as a molecular cog in the Drosophila circadian clock.
Almost three decades of investigations have resulted in an insightful model describing the …