The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Mitochondria are dynamic organelles whose functional integrity requires a coordinated
supply of proteins and phospholipids. Defined functions of specific phospholipids, like the …

Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial
roles in cardiac development and disease. Here, we combined patient-derived and …

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within
hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies …

First described in 1983, Barth syndrome (BTHS) is widely regarded as a rare X-linked
genetic disease characterised by cardiomyopathy (CM), skeletal myopathy, growth delay …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Cardiolipin, the signature phospholipid of mitochondria, is a lipid dimer that is important for a
diverse range of mitochondrial activities beyond the process of ATP production. Thus not …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz)
gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue …