Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform
chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal …

Gene expression is regulated by genomic enhancers that recruit transcription factors and
cofactors to activate transcription from target core promoters. Over the past years, thousands …

Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase
II. Multiple subunits of the complex show specificity in relaying information from signals and …

Cellular differentiation is regulated through activation and repression of defined transcription
factors. A hallmark of differentiation is a pronounced change in cell shape, which is …

Although we have made significant progress, we still possess a limited understanding of
how genomic and epigenomic information directs gene expression programs through …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …

Mediator complex (MED) is an evolutionarily conserved multiprotein, fundamental for growth
and survival of all cells. In eukaryotes, the mRNA transcription is dependent on RNA …

How lineage specifiers are regulated during development is an outstanding question, and
the molecular regulation of osteogenic factor RUNX2 remains to be fully understood. Here …