The tissue inhibitors of metalloproteinases (TIMPs) are well recognized for their role in
extracellular matrix remodeling by controlling the activity of matrix metalloproteinases …

Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in
the degradation of the extracellular matrix, play an important role in tissue remodeling …

Treatment options for late stage prostate and colon cancer are limited and there is an urgent
need to develop more effective and targeted novel therapies, which starts with identification …

Exosomes are nano-membrane vesicles that various cell types secrete during physiological
and pathophysiological conditions. By shuttling bioactive molecules such as nucleic acids …

Background Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional protein
that can directly regulate apoptosis and metastasis. In this study, we investigated the …

Background Survival for patients with castration-resistant prostate cancer is highly variable.
We assessed the effectiveness of a whole-blood RNA transcript-based model as a …

Triple-negative breast cancer (TNBC) is among the most aggressive breast cancer subtypes.
Despite being initially responsive to chemotherapy, patients develop drug-resistant and …

Background Many studies have evaluated the relationship between alkaline phosphatase
(ALP) and the prognosis for prostate cancer (PCa). But they have not reached a widespread …

Background: When single-agent androgen deprivation therapy (ADT) is administered for
locally advanced prostate cancer, men usually relapse within 1–2 years with more malignant …

Tissue inhibitor of metalloproteinase-1 (TIMP-1), a member of the TIMP family (TIMP-1 to 4),
is highly expressed in various types of cancer and forms a complex with its receptor CD63 …