The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

The innate immune system relies on its capacity to rapidly detect invading pathogenic
microbes as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Aluminium adjuvants, typically referred to as 'alum', are the most commonly used adjuvants
in human and animal vaccines worldwide, yet the mechanism underlying the stimulation of …

Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

Abstract Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-
like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we …

Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

Innate immunity confers an immediate nonspecific mechanism of microbial recognition
through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like …

Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in
innate immune responses remains unclear. Here we found that intestinal phagocytes were …

The innate immune system recognizes nucleic acids during infection and tissue damage.
Whereas viral RNA is detected by endosomal toll-like receptors (TLR3, TLR7, TLR8) and …