Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the …

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …

Recent evidence indicates a link between gut pathology and microbiome with hypertension
(HTN) in animal models. However, whether this association exists in humans is unknown …

The immune system has tailored its effector functions to optimally respond to distinct species
of microbes. Based on emerging knowledge on the different effector T-cell and innate …

Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating
the allergic and asthmatic inflammatory response pathways. One major factor limiting the …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

Inflammatory bowel disease (IBD) results from a complex series of interactions between
susceptibility genes, the environment, and the immune system. The host microbiome, as well …