The multifaceted role of glutathione S-transferases in cancer

A Chatterjee, S Gupta - Cancer letters, 2018 - Elsevier
Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the
maintenance of cell integrity, oxidative stress and protection against DNA damage by …

GST genes polymorphisms and the risk of colorectal cancer development

J Klusek, S Głuszek, J Klusek - Contemporary Oncology/Współczesna …, 2014 - termedia.pl
Increasingly often, molecular studies of colorectal cancer focus on low penetrance genes.
Among the factors potentially modifying the risk of contracting colorectal cancer is the …

[PDF][PDF] Glutathione S transferases: biochemistry, polymorphism and role in colorectal carcinogenesis

S Nissar, AS Sameer, R Rasool, NA Chowdri… - J. Carcinog …, 2017 - researchgate.net
The cytosolic GSTs are the most complex family with seven sub divisions or classes
designated as Alpha, Mu, Omega, Pi, Sigma, Theta and Zeta. Classification is based on …

GSTM1 polymorphism contribute to colorectal cancer in Asian populations: a prospective meta-analysis

J Li, W Xu, F Liu, S Huang, M He - Scientific Reports, 2015 - nature.com
Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play
important roles in neutralization of toxic compounds and protecting hosts against cancer …

Association of glutathione S-transferase M1 polymorphisms in the colorectal cancer risk: A meta-analysis

M Huang, Y Zeng, F Zhao, Y Huang - Journal of Cancer Research …, 2018 - journals.lww.com
Purpose: The glutathione S-transferase M1 (GSTM1) as a member of phase II detoxification
enzymes is expressed in many tissues and plays a critical role in preventing the occurrence …

An updated meta-analysis of the association between GSTM1 polymorphism and colorectal cancer in Asians

X Cai, L Yang, H Chen, C Wang - Tumor Biology, 2014 - Springer
Glutathione S-transferases (GSTs) are a large family of phase II detoxification enzymes that
are expressed in many tissues and play critical roles in protecting hosts against cancer. The …

[PDF][PDF] GSTM1 gene polymorphism and the risk of colorectal cancer in a Saudi Arabian population

MN Khabaz, T Nedjadi, MA Gari, JA Al-Maghrabi… - Genet Mol …, 2016 - funpecrp.com.br
The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene.
Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms …

Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study

N Masood, A Mubashar, A Yasmin - Cancer Biomarkers, 2015 - content.iospress.com
OBJECTIVE: This study was designed to evaluate association of GSTM1 and GSTT1
deletion along with epidemiological factors with risk of colon and rectum cancers …

GSTM1-null Genotype as a Risk Factor for Sporadic Colorectal Cancer in a Romanian Population. Association with the NAT2-rapid-acetylator Phenotype and …

LM Procopciuc, G Osian - Cancer investigation, 2014 - Taylor & Francis
We evaluated the association between the presence of the GSTM1-null genotype and the
combined presence of the GSTM1-null genotype/NAT2 rapid acetylator phenotype and the …

[PDF][PDF] Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic …

M Zeng, Y Lv, HF Wang, HA Yiguli, JR Zhang… - Genet Mol …, 2015 - geneticsmr.com
This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms
and environmental factors to familial aggregation of esophageal cancer (EC) among the …