BACKGROUND Reproductive disorders and infertility are associated with the risk of
obstetric complications and have a negative impact on pregnancy outcome. Affected …

BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

The central role of inflammatory processes in labour and delivery is now well-recognised.
However, the biomolecular, immunological and endocrine mechanisms involved in the …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …

The steroid hormone progesterone acting via the nuclear progesterone receptor (PR)
isoforms, progesterone receptor A (PR-A) and progesterone receptor B (PR-B), is essential …

Endometrial cancer (EC) is characterized by high estrogen levels unopposed by
progesterone. Treatment with progestins is standard for early EC, but the response to …

Myometrium holds the structural integrity for the uterus and generates force for parturition
with its primary component, the smooth muscle cells. The progesterone receptor mediates …

The steroid hormone progesterone (P4), acting via the nuclear P4 receptors (PRs) in uterine
cells, is essential for the establishment and maintenance of pregnancy. P4/PR signaling …