Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

The randomized, controlled STOP-IgAN trial in patients with IgA nephropathy (IgAN) and
substantial proteinuria showed no benefit of immunosuppression added on top of supportive …

Background Cardiac surgery is associated with a high risk of postoperative acute kidney
injury (AKI) and subsequent loss of kidney function. We explored the clinical utility of urinary …

Diabetic nephropathy (DN) is characterized by abnormal kidney energy metabolism, but its
causes and contributions to DN pathogenesis are not clear. To examine this issue, we …

Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. Through its effect on cardiovascular risk and end-stage kidney disease, CKD …

Aim How can we convert biomarkers into reliable, validated laboratory tests? Glomerular
filtration rate (GFR) estimators exist for more than a century. The first utilitarian biomarkers …

Abstract Background The EFLM Task and Finish Group Urinalysis has updated the ECLM
European Urinalysis Guidelines (2000) on urinalysis and urine bacterial culture, to improve …

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide, with varied clinical and histopathological features between individuals …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …