Introduction: There has long been an interest in the effects of diet on mental health, and the
interaction of the two with stress; however, the nature of these relationships is not well …

We conducted this meta-analysis of double-blind randomized placebo-controlled trials to
estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …

Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been proposed as
(adjuvant) treatment for major depressive disorder (MDD). In the present meta-analysis, we …

This study explores whether inflammatory biomarkers act as moderators of clinical response
to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred …

Major depressive disorder (MDD) is a complex mental illness with unmet therapeutic needs.
The antidepressant effects of ω–3 polyunsaturated fatty acids (n–3 PUFAs) have been …

Abstract Long-chain (LC) n-3 polyunsaturated fatty acids (n-3 PUFAs), in particular
docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are nutrients involved in …

Major depressive disorder (MDD) is a complex illness and it is likely that alterations in
several interacting systems underlie its pathogenesis. Numerous hypotheses have been …