Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Ancient pathogen genomics as an emerging tool for infectious disease research
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …
high-throughput sequencing, has triggered considerable progress in the study of ancient …
[HTML][HTML] Human monkeypox–After 40 years, an unintended consequence of smallpox eradication
K Simpson, D Heymann, CS Brown, WJ Edmunds… - Vaccine, 2020 - Elsevier
Smallpox eradication, coordinated by the WHO and certified 40 years ago, led to the
cessation of routine smallpox vaccination in most countries. It is estimated that over 70% of …
cessation of routine smallpox vaccination in most countries. It is estimated that over 70% of …
Ten millennia of hepatitis B virus evolution
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health
problem, but its past diversity and dispersal routes are largely unknown. We generated HBV …
problem, but its past diversity and dispersal routes are largely unknown. We generated HBV …
Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age
INTRODUCTION Variola virus (VARV), the causative agent of smallpox, is estimated to have
killed between 300 million and 500 million people in the 20 th century and was …
killed between 300 million and 500 million people in the 20 th century and was …
The evolution and clinical impact of hepatitis B virus genome diversity
The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
Measles virus and rinderpest virus divergence dated to the sixth century BCE
Many infectious diseases are thought to have emerged in humans after the Neolithic
revolution. Although it is broadly accepted that this also applies to measles, the exact date of …
revolution. Although it is broadly accepted that this also applies to measles, the exact date of …
Evidence for early domestic yak, taurine cattle, and their hybrids on the Tibetan Plateau
N Chen, Z Zhang, J Hou, J Chen, X Gao, L Tang… - Science …, 2023 - science.org
Domestic yak, cattle, and their hybrids are fundamental to herder survival at high altitudes on
the Tibetan Plateau. However, little is known about their history. Bos remains are uncommon …
the Tibetan Plateau. However, little is known about their history. Bos remains are uncommon …
Prisoners of war—host adaptation and its constraints on virus evolution
Recent discoveries of contemporary genotypes of hepatitis B virus and parvovirus B19 in
ancient human remains demonstrate that little genetic change has occurred in these viruses …
ancient human remains demonstrate that little genetic change has occurred in these viruses …
A 5700 year-old human genome and oral microbiome from chewed birch pitch
The rise of ancient genomics has revolutionised our understanding of human prehistory but
this work depends on the availability of suitable samples. Here we present a complete …
this work depends on the availability of suitable samples. Here we present a complete …