Nociceptors—noxious stimulus detectors
CJ Woolf, Q Ma - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
Novel class of pain drugs based on antagonism of NGF
FF Hefti, A Rosenthal, PA Walicke, S Wyatt… - Trends in …, 2006 - cell.com
Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …
Intracellular signaling in primary sensory neurons and persistent pain
JK Cheng, RR Ji - Neurochemical research, 2008 - Springer
During evolution, living organisms develop a specialized apparatus called nociceptors to
sense their environment and avoid hazardous situations. Intense stimulation of high …
sense their environment and avoid hazardous situations. Intense stimulation of high …
Satellite glial cells in sensory ganglia: their possible contribution to inflammatory pain
P Dublin, M Hanani - Brain, behavior, and immunity, 2007 - Elsevier
Neurons in dorsal root ganglia (DRG) are surrounded by an envelope of satellite glial cells
(SGCs). Little is known about SGC physiology and their interactions with neurons. In this …
(SGCs). Little is known about SGC physiology and their interactions with neurons. In this …
Understanding inflammatory pain: ion channels contributing to acute and chronic nociception
Inflammatory pain results from the increased excitability of peripheral nociceptive sensory
fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a …
fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a …
[HTML][HTML] Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
GD Nicol, MR Vasko - Molecular interventions, 2007 - triggered.edina.clockss.org
Abstract Nerve Growth Factor (NGF) is produced by and affects a number of immune and
inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the …
inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the …
Activation of JNK pathway in persistent pain
The c-Jun N-terminal kinase (JNK) is a stress-activated member of MAP kinase family. JNK
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
D-serine signalling in the brain: friend and foe
M Martineau, G Baux, JP Mothet - Trends in neurosciences, 2006 - cell.com
Neurons and glia talk to each other at synapses. Glia sense the level of synaptic activity and
consequently regulate its efficacy via the release of neuromodulators. One such glia-derived …
consequently regulate its efficacy via the release of neuromodulators. One such glia-derived …
Taking pain out of NGF: a “painless” NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity
During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors,
thereby increasing the response to noxious stimuli. The relationship between NGF and pain …
thereby increasing the response to noxious stimuli. The relationship between NGF and pain …
[HTML][HTML] Acetic acid-and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI3K and microglia in mice
GF Pavao-de-Souza, AC Zarpelon, GC Tedeschi… - Pharmacology …, 2012 - Elsevier
The acetic acid and phenyl-p-benzoquinone are easy and fast screening models to access
the activity of novel candidates as analgesic drugs and their mechanisms. These models …
the activity of novel candidates as analgesic drugs and their mechanisms. These models …