Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

Diagnosis and management of the antiphospholipid syndrome

D Garcia, D Erkan - New England Journal of Medicine, 2018 - Mass Medical Soc
Antiphospholipid Syndrome Antiphospholipid antibodies can induce endothelial-cell,
complement, platelet, neutrophil, and monocyte activation, leading to thrombosis, renal …

Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome

V Pengo, G Denas, G Zoppellaro… - Blood, The Journal …, 2018 - ashpublications.org
Rivaroxaban is an effective and safe alternative to warfarin in patients with atrial fibrillation
and venous thromboembolism. We tested the efficacy and safety of rivaroxaban compared …

Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS

S Chaturvedi, EM Braunstein, X Yuan… - Blood, The Journal …, 2020 - ashpublications.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy
morbidity in the presence of antiphospholipid antibodies, including anti-β2-glycoprotein-I …

The pathogenesis of the antiphospholipid syndrome

B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

[PDF][PDF] Guidelines on the investigation and management of antiphospholipid syndrome.

D Keeling, I Mackie, GW Moore, IA Greer… - British journal of …, 2012 - academia.edu
1Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, Oxford, UK, 2Haemostasis
Research Unit, Haematology Department, University College London, London, UK, 3Centre …

Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study

V Pengo, A Ruffatti, C Legnani, S Testa… - Blood, The Journal …, 2011 - ashpublications.org
Persistent antiphospholipid (aPL) antibodies are occasionally found in subjects without prior
history of thromboembolic events (TEs), raising the dilemma of whether to initiate or not a …

Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study

RT Urbanus, B Siegerink, M Roest… - The Lancet …, 2009 - thelancet.com
Background Arterial thrombosis is a major clinical manifestation of the antiphospholipid
syndrome, which is an autoimmune disease found mostly in young women. Although the …

Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events

K Otomo, T Atsumi, O Amengual, Y Fujieda… - Arthritis & …, 2012 - Wiley Online Library
Objective To define the antiphospholipid score (aPL‐S) by testing multiple antiphospholipid
antibodies (aPL) and to evaluate its efficacy for the diagnosis of antiphospholipid syndrome …

Complement in the pathophysiology of the antiphospholipid syndrome

S Chaturvedi, RA Brodsky, KR McCrae - Frontiers in immunology, 2019 - frontiersin.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …