RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

INTRODUCTION The ribosome catalyzes protein synthesis in all cells by coupling the
decoding of messenger RNA by the small ribosomal subunit with peptide bond formation by …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in
yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding …

Mutations that target the ubiquitous process of ribosome assembly paradoxically cause
diverse tissue-specific disorders (ribosomopathies) that are often associated with an …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …