DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …

Topoisomerases are complex molecular machines that modulate DNA topology to maintain
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …

The SOS response in UV-irradiated Escherichia coli includes the upregulation of several
dozen genes that are negatively regulated by the LexA repressor. Using DNA microarrays …

Background Bacterial populations contain persisters, phenotypic variants that constitute
approximately 1% of cells in stationary phase and biofilm cultures. Multidrug tolerance of …

Oligonucleotide microarrays were used to map the detailed topography of chromosome
replication in the budding yeast Saccharomyces cerevisiae. The times of replication of …

The emergence of drug-resistant bacteria poses a serious threat to human health. In the
case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria …

The bacterial chromosome must be compacted more than 1,000-fold to fit into the
compartment in which it resides. How it is condensed, organized and ultimately segregated …

Gepotidacin is a first-in-class triazaacenaphthylene novel bacterial topoisomerase inhibitor
(NBTI). The compound has successfully completed phase II trials for the treatment of acute …

We present the complete genome sequence of Yersinia pestis KIM, the etiologic agent of
bubonic and pneumonic plague. The strain KIM, biovar Mediaevalis, is associated with the …

Fluoroquinolones trap gyrase and topoisomerase IV on DNA as ternary complexes that
block the movement of replication forks and transcription complexes. Studies with resistant …