Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

GF Rushworth, IL Megson - Pharmacology & therapeutics, 2014 - Elsevier
Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …

[HTML][HTML] Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities

J González-Montero, R Brito, AIJ Gajardo… - World journal of …, 2018 - ncbi.nlm.nih.gov
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Its associated
mortality, morbidity and complications have significantly decreased with the development of …

Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential

KP Shay, RF Moreau, EJ Smith, AR Smith… - Biochimica et Biophysica …, 2009 - Elsevier
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

Lipoic acid–biological activity and therapeutic potential

A Gorąca, H Huk-Kolega, A Piechota… - Pharmacological …, 2011 - Elsevier
Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential

L Rochette, S Ghibu, C Richard, M Zeller… - Molecular nutrition & …, 2013 - Wiley Online Library
Diabetes has emerged as a major threat to worldwide health. The exact mechanisms
underlying the disease are unknown; however, there is growing evidence that the excess …

[图书][B] Oxidation and antioxidants in organic chemistry and biology

ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress

AR Smith, SV Shenvi, M Widlansky… - Current medicinal …, 2004 - ingentaconnect.com
α-Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an
essential cofactor for mitochondrial bioenergetic enzymes. Aside from its enzymatic role, in …

Mercury toxicity and antioxidants: part I: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.(Mercury Toxicity)

L Patrick - Alternative Medicine Review, 2002 - go.gale.com
Mercury exposure is the second-most common cause of toxic metal poisoning. Public health
concern over mercury exposure, due to contamination of fish with methylmercury and the …

Contributions of blood and blood components to lipid oxidation in fish muscle

MP Richards, HO Hultin - Journal of Agricultural and Food …, 2002 - ACS Publications
There was a wide variation in the amounts of hemoglobin extracted from the muscle tissue of
bled and unbled fish. Averaged values suggested that the residual blood level in the muscle …

[图书][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …