Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Membrane association with mother centriole (M-centriole) distal appendages is critical for
ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary …

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic
disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Primary cilia, microtubule-based sensory structures, orchestrate various critical signals
during development and tissue homeostasis. In view of the rising interest into the reciprocal …

The primary cilium, a sensory appendage that is present in most mammalian cells, plays
critical roles in signaling pathways and cell cycle progression. Mutations that affect the …