Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a
unique class of diversified frameworks displaying a broad spectrum of biological functions …

Thymidine phosphorylase (TP), also referred to as “platelet-derived endothelial cell growth
factor” is crucial to the pyrimidine salvage pathway. TP reversibly transforms thymidine into …

(4-Fluorophenyl)-quinazolin-4 (3H)-one (FQ) was synthesized, and its structure was
identified with 1 H nuclear magnetic resonance (1 H NMR), 13 C nuclear magnetic …

The chemical structure of quinazolinones includes benzene ring fused with 2-pyrimidinone
(1), 4-pyrimidinone (2) or 2, 4-pyrimidinedione (3) ring, and are named as quinazolin-2 (1H) …

Abstract A variety of dihydroquinazolin-4 (1 H)-one derivatives (1–37) were synthesized via
“one-pot” three-component reaction scheme by treating aniline and different aromatic …

We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated
their inhibition constants. We synthesized 2-(2, 6-dimethylhepta-1, 5-dien-1-yl) quinazolin-4 …

Abstract Thymidine phosphorylase (TP, EC 2.4. 2.4), an enzyme involved in pyrimidine
salvage pathway, is identical to platelet-derived endothelial cell growth factor (PD-ECGF) …

Background: Moringa peregrina is widely used in the traditional medicine of the Arabian
Peninsula to treat various ailments, because it has many pharmacologically active …

Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological
complications, including angiogenesis which leads to cancer cells proliferation. Thus in …

Natural flora is the richest source of novel therapeutic agents due to their immense chemical
diversity and novel biological properties. In this regard, eighteen natural products belonging …