Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

TANK-binding kinase 1 (TBK1) is a member of the IKK family and plays a crucial role in the
activation of non-canonical NF-κB signaling and type I interferon responses. The aberrant …

African swine fever (ASF) is originally reported in East Africa as an acute hemorrhagic fever.
African swine fever virus (ASFV) is a giant and complex DNA virus with icosahedral structure …

Since invasion, there will be a tug-of-war between host and virus to scramble cellular
resources, for either restraining or facilitating infection. Alternative splicing (AS) is a …

The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of
IFN-β and many other genes associated with the immune response activation in vertebrates …

Although cancer immunotherapy has become a successful therapeutic strategy in a certain
range of solid cancer and hematological malignancies, this efficacy of immunotherapy is …

Cancer is a global health concern with rising incidence, morbidity, and mortality. The
interaction between the tumor and immune cells within the tumor microenvironment is …

Abstract TANK-binding kinase 1 (TBK1) undergoes alternative splicing, and the previously
reported TBK1 isoforms are negative regulators of RIG-I–like receptor–mediated type I IFN …

Background. Alternative splicing (AS) plays a crucial role in regulating the progression of
colorectal cancer (CRC), but its distribution remains to be explored. Here, we aim to …