Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
I Schwartz, V Budroni, M Meyenberg, H Hornegger… - bioRxiv, 2024 - biorxiv.org
Abstract Highlights RNA-free APOBEC3 (A3) can enter the nucleus, leading to genomic
mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s …
mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s …
TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases
A Shulkina, K Hacker, JF Ehrmann, V Budroni… - bioRxiv, 2024 - biorxiv.org
Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many
other mammals. In contrast to what one would expect for such a non-conserved factor …
other mammals. In contrast to what one would expect for such a non-conserved factor …
ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA
A Soderholm, M Vunjak, M DeAlmeida, N Popitsch… - bioRxiv, 2024 - biorxiv.org
Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective
immunological checkpoint blockade in cancer immunotherapy. Genetic screen identification …
immunological checkpoint blockade in cancer immunotherapy. Genetic screen identification …