Mitochondria are cellular organelles critical for ATP production and are particularly relevant
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …

Background & Aims Fibroblasts play a key role in stricture formation in Crohn's disease (CD)
but understanding its pathogenesis requires a systems-level investigation to uncover new …

Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis but the
mechanisms by which CH mutant cells transmit inflammatory signals to non-mutant cells are …

Fibroblasts are abundant stromal cells which not only control the integrity of extracellular
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …

Perivascular adipose tissue (PVAT) regulates vascular function due to its capacity to
synthesize vasoactive products and its mechanical properties. PVATs most abundant cells …

Large-vessel vasculitides (LVV) comprise a group of chronic inflammatory diseases of the
aorta and its major branches. The most common forms of LVV are giant cell arteritis (GCA) …

Coronary microvascular disease (CMD) and its progression towards major adverse coronary
events pose a significant health challenge. Accurate in vitro investigation of CMD requires a …

Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the
advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an …

Atherosclerotic plaque rupture mainly contributes to acute coronary syndrome (ACS).
Insufficient repair of these plaques leads to thrombosis and subsequent ACS. Central to this …

Hypertension is a major cause of cardiovascular diseases such as myocardial infarction and
stroke. Cardiovascular fibrosis occurs with hypertension and contributes to vascular …