Treatment-refractory giardiasis: challenges and solutions

M Lalle, K Hanevik - Infection and drug resistance, 2018 - Taylor & Francis
Giardia is the commonest parasitic diarrheal pathogen affecting humans and a frequent
cause of waterborne/foodborne parasitic diseases worldwide. Prevalence of giardiasis is …

Giardiasis: an overview

AKC Leung, AAM Leung, AHC Wong… - Recent patents on …, 2019 - ingentaconnect.com
Background: Giardiasis is an important cause of waterborne and foodborne diarrhea,
daycare center outbreaks, and traveler's diarrhea. Objective: The study aimed to provide an …

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

R Argüello-García, D Leitsch, T Skinner-Adams… - Advances in …, 2020 - Elsevier
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

Anti-Giardia Drug Discovery: Current Status and Gut Feelings

A Riches, CJS Hart, KR Trenholme… - Journal of medicinal …, 2020 - ACS Publications
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …

Giardiasis

C Minetti, RM Chalmers, NJ Beeching, C Probert… - Bmj, 2016 - bmj.com
Box 1 summarises the risk factors for acquisition of Giardia in high income countries. Travel
to low income settings is a common risk factor, with the highest risk areas being South Asia …

[HTML][HTML] Giardiasis treatment: an update with a focus on refractory disease

K Mørch, K Hanevik - Current Opinion in Infectious Diseases, 2020 - journals.lww.com
A combination of a 5-nitroimidazole and albendazole or mebendazole, and quinacrine
monotherapy, are rational choices in nitroimidazole refractory infections, but randomized …

[HTML][HTML] Nitroimidazole-refractory giardiasis: a growing problem requiring rational solutions

ER Carter, LE Nabarro, L Hedley… - Clinical microbiology and …, 2018 - Elsevier
Background Giardia intestinalis is microaerophilic diarrhoea-causing protozoan common in
countries with suboptimal sanitation. Standard treatment is with nitroimidazoles, but a …

Treatment strategies for nitroimidazole-refractory giardiasis: a systematic review

DL Bourque, A Neumayr, M Libman… - Journal of travel …, 2022 - academic.oup.com
Rationale for review Giardiasis is one of the most common human protozoal infections
worldwide. First-line therapy of giardiasis includes nitroimidazole antibiotics. However …

Potent efficiency of the novel nitazoxanide-loaded nanostructured lipid carriers against experimental cyclosporiasis

NA Hagras, S Makled, E Sheta… - PLoS Neglected …, 2023 - journals.plos.org
Cyclosporiasis is a ubiquitous infection caused by an obligate intracellular protozoan
parasite known as Cyclospora cayetanensis (C. cayetanensis). The disease is characterized …

Efficacy and tolerability of quinacrine monotherapy and albendazole plus chloroquine combination therapy in nitroimidazole-refractory giardiasis: a TropNet study

A Neumayr, M Schunk, C Theunissen… - Clinical Infectious …, 2021 - academic.oup.com
Background Giardiasis failing nitroimidazole first-line treatment is an emerging problem in
returning European travelers. We present data on the efficacy and tolerability of 2 second …