Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual
neurons, taken out of their developmental context, readily form unspecific synapses. How …

Neurexins are widely thought to promote synapse formation and to organize synapse
properties. Here we found that in contrast to neurexin-1 and neurexin-3, neurexin-2 …

Synaptic adhesion molecules (SAMs) shape the structural and functional properties of
synapses and thereby control the information processing power of neural circuits. SAMs are …

Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity
of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in …

Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by
parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is …

Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …

Prenatal maternal stress has a negative impact on child health but the mechanisms through
which maternal stress affects child health are unclear. Epigenetic variation, such as DNA …

In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate
intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion …

The human brain undergoes protracted postnatal maturation, guided by dynamic changes in
gene expression. Most studies exploring these processes have used bulk tissue analyses …

Huntington's disease and juvenile-onset schizophrenia have long been regarded as distinct
disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with …