Microenvironment imbalance of spinal cord injury

B Fan, Z Wei, X Yao, G Shi, X Cheng… - Cell …, 2018 - journals.sagepub.com
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

[HTML][HTML] Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

J Li, W Luo, C Xiao, J Zhao, C Xiang, W Liu, R Gu - Theranostics, 2023 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically
available treatments are quite limited, with unsatisfactory remediation effects. Residing …

Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury

L Li, Y Zhang, J Mu, J Chen, C Zhang, H Cao, J Gao - Nano letters, 2020 - ACS Publications
Spinal cord injury is among the most fatal diseases. The complicated inhibitory
microenvironment requires comprehensive mitigation. Exosomes derived from …

Adhesive, stretchable, and spatiotemporal delivery fibrous hydrogels harness endogenous neural stem/progenitor cells for spinal cord injury repair

Z Chen, H Zhang, C Fan, Y Zhuang, W Yang, Y Chen… - ACS …, 2021 - ACS Publications
Aligned fibrous hydrogels capable of recruiting endogenous neural stem/progenitor cells
(NSPCs) show great promise in spinal cord injury (SCI) repair. However, the hydrogels …

A phase III clinical trial showing limited efficacy of autologous mesenchymal stem cell therapy for spinal cord injury

SK Oh, KH Choi, JY Yoo, DY Kim, SJ Kim… - Neurosurgery, 2016 - journals.lww.com
BACKGROUND: In our previous report, 3 of 10 patients with spinal cord injury who were
injected with autologous mesenchymal stem cells (MSCs) showed motor improvement in the …

[HTML][HTML] In vivo reprogramming for CNS repair: regenerating neurons from endogenous glial cells

H Li, G Chen - Neuron, 2016 - cell.com
Neuroregeneration in the CNS has proven to be difficult despite decades of research. The
old dogma that CNS neurons cannot be regenerated in the adult mammalian brain has been …

Stem cells therapy for spinal cord injury

M Gazdic, V Volarevic, CR Harrell… - International journal of …, 2018 - mdpi.com
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously
healthy young adults. Current therapeutic strategies for SCI includes surgical …

The uptake mechanism and biocompatibility of graphene quantum dots with human neural stem cells

W Shang, X Zhang, M Zhang, Z Fan, Y Sun, M Han… - Nanoscale, 2014 - pubs.rsc.org
Cellular imaging after transplantation may provide important information to determine the
efficacy of stem cell therapy. We have reported that graphene quantum dots (GQDs) are a …

Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair

Y Zou, D Ma, H Shen, Y Zhao, B Xu, Y Fan, Z Sun… - Biomaterials …, 2020 - pubs.rsc.org
Neural stem/progenitor cell (NSPC)-based spinal cord injury (SCI) therapy is expected to
bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells. The …

Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury

S Wang, H Cheng, G Dai, X Wang, R Hua, X Liu… - Brain research, 2013 - Elsevier
The aim of this study was to investigate the effects of transplantation with umbilical cord
mesenchymal stem cells in patients with sequelae of traumatic brain injury (TBI). The study …