Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Y Zhang, RA Weinberg - Frontiers of medicine, 2018 - Springer
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …

Non-redundant functions of EMT transcription factors

MP Stemmler, RL Eccles, S Brabletz, T Brabletz - Nature cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

T Shibue, RA Weinberg - Nature reviews Clinical oncology, 2017 - nature.com
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Oncogenic roles of EMT-inducing transcription factors

A Puisieux, T Brabletz, J Caramel - Nature cell biology, 2014 - nature.com
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Signaling mechanisms of the epithelial-mesenchymal transition

DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …

The basics of epithelial-mesenchymal transition

R Kalluri, RA Weinberg - The Journal of clinical …, 2009 - Am Soc Clin Investig
The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …

Epithelial-mesenchymal transitions: insights from development

J Lim, JP Thiery - Development, 2012 - journals.biologists.com
Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that
occurs during development and is essential for shaping embryos. Also implicated in cancer …

Transcriptional regulation of EMT transcription factors in cancer

M Saitoh - Seminars in Cancer Biology, 2023 - Elsevier
The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

J Yang, RA Weinberg - Developmental cell, 2008 - cell.com
The epithelial-mesenchymal transition is a highly conserved cellular program that allows
polarized, immotile epithelial cells to convert to motile mesenchymal cells. This important …