Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

Granulation is one of the fundamental operations in particulate processing and has a very
ancient history and widespread use. Much fundamental particle science has occurred in the …

The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

The study of breakage in granulation is important from a process and from a product quality
perspective. Breakage is considered an important rate process in granulation, and plays …

A comprehensive model is discussed for wet granulation based on a three-dimensional
population balance, as an attempt to capture particle-level phenomena and their influence …

Granulation is a process whereby a dense colloidal suspension is converted into pasty
granules (surrounded by air) by application of shear. Central to the stability of the granules is …

In this study, a dynamic model is presented for the granulation process, employing a three-
dimensional population balance framework. The major focus of this work is the theoretical …

High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging
task. Scale-up of high-shear wet granulation process has been studied extensively in the …

Seeded granulation is one of the recently adopted wet granulation techniques. The seeded
granules consist of high-density core nuclei and low-density particles layered on the outside …

The conventional, geometrically lumped description of the physical processes inside a high
shear granulator is not reliable for process design and scale‐up. In this study, a …