Effects of single and combined toxic exposures on the gut microbiome: Current knowledge and future directions
Human populations are chronically exposed to mixtures of toxic chemicals. Predicting the
health effects of these mixtures require a large amount of information on the mode of action …
health effects of these mixtures require a large amount of information on the mode of action …
[HTML][HTML] Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease
S Zheng, Y Yang, C Wen, W Liu, L Cao, X Feng… - Environment …, 2021 - Elsevier
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …
Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food
EFSA Panel on Contaminants in the Food Chain … - Efsa …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism
Abstract 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …
AhR activation leads to alterations in the gut microbiome with consequent effect on induction of myeloid derived suppressor cells in a CXCR2-dependent manner
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) is a potent ligand for AhR and a known carcinogen …
tetrachlorodibenzo-p-dioxin (TCDD) is a potent ligand for AhR and a known carcinogen …
Chronic exposure of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet
A Brulport, L Le Corre, MC Chagnon - Toxicology, 2017 - Elsevier
Contaminant involvement in the pathophysiology of obesity is widely recognized. It has been
shown that low dose and chronic exposure to endocrine disruptor compounds (EDCs) …
shown that low dose and chronic exposure to endocrine disruptor compounds (EDCs) …
Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis
We have previously shown that in response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-
elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism …
elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism …
Flux, impact, and fate of halogenated xenobiotic compounds in the gut
Humans and their associated microbiomes are exposed to numerous xenobiotics through
drugs, dietary components, personal care products as well as environmental chemicals …
drugs, dietary components, personal care products as well as environmental chemicals …
Persistent organic pollutants and metabolic diseases: From the perspective of lipid droplets
H Hou, Y Ji, Y Pan, L Wang, Y Liang - Environmental Pollution, 2024 - Elsevier
The characteristic of semi-volatility enables persistent organic pollutants (POPs) almost
ubiquitous in the environment. There is increasing concern about the potential risks of …
ubiquitous in the environment. There is increasing concern about the potential risks of …
Persistent endocrine-disrupting chemicals and fatty liver disease
AL Deierlein, S Rock, S Park - Current environmental health reports, 2017 - Springer
Abstract Purpose of Review Non-alcoholic fatty liver disease (NAFLD) is the most prominent
chronic liver disease in Western countries, affecting approximately 25% of the population …
chronic liver disease in Western countries, affecting approximately 25% of the population …