Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
Engineering synthetic RNA devices for cell control
The versatility of RNA in sensing and interacting with small molecules, proteins and other
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …
nucleic acids while encoding genetic instructions for protein translation makes it a powerful …
Inducible and reversible RNA N6-methyladenosine editing
RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate
fundamental RNA processes and properties, and directly linked to various human diseases …
fundamental RNA processes and properties, and directly linked to various human diseases …
Programmable RNA base editing via targeted modifications
Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editors
are powerful tools in biology and hold great promise for the treatment of human diseases …
are powerful tools in biology and hold great promise for the treatment of human diseases …
A methylation-and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance
L Chen, W Gao, L Lin, C Sha, T Li, Q Chen… - Journal of Ovarian …, 2023 - Springer
Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune
escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms …
escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms …
RNA-targeting strategies as a platform for ocular gene therapy
Genetic medicine is offering hope as new therapies are emerging for many previously
untreatable diseases. The eye is at the forefront of these advances, as exemplified by the …
untreatable diseases. The eye is at the forefront of these advances, as exemplified by the …
[HTML][HTML] Context-aware synthetic biology by controller design: Engineering the mammalian cell
The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
[HTML][HTML] Advance trends in targeting homology-directed repair for accurate gene editing: An inclusive review of small molecules and modified CRISPR-Cas9 systems
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Introduction: Clustered regularly interspaced short palindromic repeat and its associated …
Introduction: Clustered regularly interspaced short palindromic repeat and its associated …
A split CRISPR/Cas13b system for conditional RNA regulation and editing
The CRISPR/Cas13b system has been demonstrated as a robust tool for versatile RNA
studies and relevant applications. New strategies enabling precise control of …
studies and relevant applications. New strategies enabling precise control of …
NLDock: A fast nucleic acid–ligand docking algorithm for modeling RNA/DNA–ligand complexes
Nucleic acid–ligand interactions play an important role in numerous cellular processes such
as gene function expression and regulation. Therefore, nucleic acids such as RNAs have …
as gene function expression and regulation. Therefore, nucleic acids such as RNAs have …