P: 9 Pharmacotherapies that Specifically Target Ammonia for the Prevention and Treatment of Hepatic Encephalopathy in Adults With Crrhosis

HD Zacharias, AP Zacharias, LL Gluud… - Official journal of the …, 2019 - journals.lww.com
BACKGROUND: Ammonia plays a key role in the genesis of hepatic encephalopathy (HE).
Recent interest has focused on drugs which specifically target ammonia, eg sodium …

Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis

HD Zacharias, F Kamel, J Tan, N Kimer… - Cochrane Database …, 2023 - cochranelibrary.com
Background Hepatic encephalopathy describes the spectrum of neuropsychiatric changes
that may complicate the course of cirrhosis and detrimentally affect outcomes. Ammonia …

Stepwise diagnosis in covert hepatic encephalopathy: critical flicker frequency and MELD‐score as a first‐step approach

R Greinert, C Ripoll, M Hollenbach… - Alimentary …, 2016 - Wiley Online Library
Background The diagnosis of covert hepatic encephalopathy (CHE) by means of
portosystemic encephalopathy syndrome (PSE) test is costly and therefore infrequently …

Critical flickering frequency test: a diagnostic tool for minimal hepatic encephalopathy

MA Metwally, HA Biomy, MZ Omar… - European Journal of …, 2019 - journals.lww.com
Background Minimal hepatic encephalopathy (MHE) is underestimated. It affects 30–55% of
patients with liver cirrhosis and can change their daily functions. Psychometric tests are …

Hepatic encephalopathy in patients with cirrhosis

MY Morgan - Sherlock's Diseases of the Liver and Biliary …, 2011 - Wiley Online Library
Hepatic encephalopathy is the commonest complication of cirrhosis. It comprises a spectrum
of neuropsychiatric abnormalities ranging from subtle changes in cognition to clinically …

Outcomes in clinical trials evaluating interventions for the prevention and treatment of hepatic encephalopathy

LL Gluud, R Jeyaraj, MY Morgan - Journal of Clinical and Experimental …, 2019 - Elsevier
Randomised clinical trials and systematic reviews of research findings can provide high-
quality evidence for decision-making in the management of patients with hepatic …