All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …

Local translation allows spatial control of gene expression. Here, we performed a dual
protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP …

INTRODUCTION Most newly synthesized proteins associate into macromolecular
complexes to become functional. Complex formation requires that subunits find each other …

In recent years translation elongation has emerged as an important contributor to the
regulation of gene expression. There are multiple quality control checkpoints along the way …

Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

Translation initiation is the major regulatory step defining the rate of protein production from
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …

Local translation allows for a spatial control of gene expression. Here, we use high-
throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human …

The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …