Mismatch repair
The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
Mismatch repair during homologous and homeologous recombination
Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
[HTML][HTML] Strand discrimination in DNA mismatch repair
CD Putnam - DNA repair, 2021 - Elsevier
DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …
Endonuclease activities of MutLα and its homologs in DNA mismatch repair
LY Kadyrova, FA Kadyrov - DNA repair, 2016 - Elsevier
MutLα is a key component of the DNA mismatch repair system in eukaryotes. The DNA
mismatch repair system has several genetic stabilization functions. Of these functions, DNA …
mismatch repair system has several genetic stabilization functions. Of these functions, DNA …
Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα
MB Firnau, G Plotz, S Zeuzem, A Brieger - Scientific Reports, 2023 - nature.com
MutLα is essential for human DNA mismatch repair (MMR). It harbors a latent endonuclease,
is responsible for recruitment of process associated proteins and is relevant for strand …
is responsible for recruitment of process associated proteins and is relevant for strand …
Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors
N Takemoto, I Numata, M Su'etsugu… - Nucleic acids …, 2018 - academic.oup.com
Mismatch repair (MMR) systems based on MutS eliminate mismatches originating from
replication errors. Despite extensive conservation of mutS homologues throughout the three …
replication errors. Despite extensive conservation of mutS homologues throughout the three …
The Nucleotide Excision Repair Pathway Protects Borrelia burgdorferi from Nitrosative Stress in Ixodes scapularis Ticks
TJ Bourret, KA Lawrence, JA Shaw, T Lin… - Frontiers in …, 2016 - frontiersin.org
The Lyme disease spirochete Borrelia burgdorferi encounters a wide range of
environmental conditions as it cycles between ticks of the genus Ixodes and its various …
environmental conditions as it cycles between ticks of the genus Ixodes and its various …
The GIY‐YIG endonuclease domain of Arabidopsis MutS homolog 1 specifically binds to branched DNA structures
K Fukui, A Harada, T Wakamatsu, A Minobe… - FEBS …, 2018 - Wiley Online Library
In plant organelle genomes, homeologous recombination between heteroallelic positions of
repetitive sequences is increased by dysfunction of the gene encoding MutS homolog 1 …
repetitive sequences is increased by dysfunction of the gene encoding MutS homolog 1 …
MutS recognition of mismatches within primed DNA replication intermediates
MII Busseti, LM Margara, SD Castell, MM Fernández… - DNA repair, 2022 - Elsevier
MutS initiates mismatch repair by recognizing mismatches in newly replicated DNA. Specific
interactions between MutS and mismatches within double-stranded DNA promote ADP-ATP …
interactions between MutS and mismatches within double-stranded DNA promote ADP-ATP …
Identification of a Catalytic Lysine Residue Conserved Among GHKL ATPases: MutL, GyrB, and MORC
K Fukui, Y Fujii, T Yano - Journal of Molecular Biology, 2024 - Elsevier
DNA mismatch repair endonuclease MutL is a member of GHKL ATPase superfamily.
Mutations of MutL homologs are causative of a hereditary cancer, Lynch syndrome. We …
Mutations of MutL homologs are causative of a hereditary cancer, Lynch syndrome. We …