The immune system plays important roles in tumor development. According to the immune-
editing theory, immune escape is the key to tumor survival, and exploring the mechanisms of …

Prostaglandin E2 (PGE2) is an important lipid mediator in inflammatory and immune
responses during acute and chronic infections. Upon stimulation by various proinflammatory …

Abstract Programmed Death-1 (PD-1), an inhibitory receptor expressed by activated
lymphocytes, is involved in regulating T-and B-cell responses. PD-1 and its ligands are …

Background Although the treatment of iatrogenic and HIV-related Kaposi sarcoma is well
defined and mostly based on restoring immune function, the treatment of classic and …

NF-κB is a key transcription factor that dictates the outcome of diverse immune responses.
How NF-κB is regulated by multiple activating receptors that are engaged during natural …

Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells
and virus-infected cells. NK cells also play an important role in the graft versus leukemia …

The development of cancer and chronic infections is facilitated by many subversion
mechanisms, among which enhanced expression of immune checkpoints molecules, such …

Simple Summary Natural killer cells are able to effectively eliminate tumor cells without
previous sensitization, therefore the interest in their application in tumor immunotherapy has …

The two human tumor viruses, Epstein–Barr virus (EBV) and Kaposi sarcoma-associated
herpesvirus (KSHV), have been mostly studied in isolation. Recent studies suggest that co …

Natural killer (NK) cells are key effectors in cancer immunosurveillance and can be used as
a prognostic biomarker in diverse cancers. Nonetheless, the role of NK cells in pancreatic …