Carnitine is an amino acid-derived substance that coordinates a wide range of biological
processes. Such functions include transport of long-chain fatty acids from the cytoplasm to …

Cardiovascular disease may be induced or worsened by mitochondrion-toxic agents.
Mitochondrion-toxic agents may be classified as those with or without a clinical effect, those …

Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to
its high antitumor efficacy in hematological as well as in solid malignancies. The clinical use …

Doxorubicin is an antibiotic broadly used in treatment of different types of solid tumors. The
present study investigates whether L‐carnitine, antioxidant agent, can reduce the hepatic …

Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and
type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that …

This study investigated whether cyclophosphamide (CP) and ifosfamide (IFO) therapy alters
the expression of the key genes engaged in long-chain fatty acid (LCFA) oxidation outside …

Background Ifosfamide (IFO) is a widely used antitumor prodrug. It is in the
oxazaphosphorine class of DNA alkylating agents and is effective against solid tumors, such …

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Introduction: Nephrotoxicity is one of the major side effects of the chemotherapeutic drug …

Significance: Survivors of pediatric cancers have a high risk of developing side effects after
the end of their treatments. Many potential factors have been associated with the onset of …

It is well documented that ifosfamide (IFO) therapy is associated with sever nephropathy in
the form of Fanconi syndrome. Although oxidative stress has been reported as a major …