Therapeutic options for targeting inflammatory osteoarthritis pain
PG Conaghan, AD Cook, JA Hamilton… - Nature Reviews …, 2019 - nature.com
Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …
manage this disease. However, the current standard of care does not provide satisfactory …
Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications
HM Chang, HC Wu, ZG Sun, F Lian… - Human reproduction …, 2019 - academic.oup.com
BACKGROUND Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor
(BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived …
(BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived …
Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives
Y El Ouaamari, J Van den Bos, B Willekens… - International journal of …, 2023 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases
A Quintero-Villegas, SI Valdés-Ferrer - Molecular Medicine, 2022 - Springer
HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin
receptors. Their role in health and disease, particularly as mediators of, and druggable …
receptors. Their role in health and disease, particularly as mediators of, and druggable …
Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration
Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-
of-function. Endogenous repair is limited to non-severe injuries in which transection of …
of-function. Endogenous repair is limited to non-severe injuries in which transection of …
Membrane lipid raft homeostasis is directly linked to neurodegeneration
Age-associated neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS),
Parkinson's disease (PD) and Alzheimer's disease (AD) are an unmet health need, with …
Parkinson's disease (PD) and Alzheimer's disease (AD) are an unmet health need, with …
The impact of physical exercise on the circulating levels of BDNF and NT 4/5: a review
(1) Background: One mechanism through which physical activity (PA) provides benefits is by
triggering activity at a molecular level, where neurotrophins (NTs) are known to play an …
triggering activity at a molecular level, where neurotrophins (NTs) are known to play an …
Peripheral mechanisms of chronic pain
Acutely, pain serves to protect us from potentially harmful stimuli, however damage to the
somatosensory system can cause maladaptive changes in neurons leading to chronic pain …
somatosensory system can cause maladaptive changes in neurons leading to chronic pain …