Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The manifold roles of microbial ribosomal peptide–based natural products in physiology and ecology

Y Li, S Rebuffat - Journal of Biological Chemistry, 2020 - ASBMB
The ribosomally synthesized and posttranslationally modified peptides (RiPPs), also called
ribosomal peptide natural products (RPNPs), form a growing superfamily of natural products …

A mycofactocin-associated dehydrogenase is essential for ethylene glycol metabolism by Rhodococcus jostii RHA1

T Shimizu, K Suzuki, M Inui - Applied Microbiology and Biotechnology, 2024 - Springer
Ethylene glycol is an industrially important diol in many manufacturing processes and a
building block of polymers, such as poly (ethylene terephthalate). In this study, we found that …

Role of premycofactocin synthase in growth, microaerophilic adaptation, and metabolism of Mycobacterium tuberculosis

G Krishnamoorthy, P Kaiser, P Constant, U Abu Abed… - Mbio, 2021 - Am Soc Microbiol
Mycofactocin is a new class of peptide-derived redox cofactors present in a selected group
of bacteria including Mycobacterium tuberculosis. Mycofactocin biosynthesis requires at …

Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF

L Peña-Ortiz, AP Graça, H Guo, D Braga… - Chemical …, 2020 - pubs.rsc.org
Mycofactocin (MFT) is a redox cofactor belonging to the family of ribosomally synthesized
and post-translationally modified peptides (RiPPs) and is involved in alcohol metabolism of …

S-Adenosylmethionine (SAM)-Dependent Methyltransferase MftM is Responsible for Methylation of the Redox Cofactor Mycofactocin

M Ellerhorst, SA Barth, AP Graça… - ACS Chemical …, 2022 - ACS Publications
Mycobacteria produce several unusual cofactors that contribute to their metabolic versatility
and capability to survive in different environments. Mycofactocin (MFT) is a redox cofactor …

The catabolism of ethylene glycol by Rhodococcus jostii RHA1 and its dependence on mycofactocin

R Roccor, ME Wolf, J Liu, LD Eltis - Applied and Environmental …, 2024 - Am Soc Microbiol
Ethylene glycol (EG) is a widely used industrial chemical with manifold applications and also
generated in the degradation of plastics such as polyethylene terephthalate. Rhodococcus …

Ms6244 is a novel Mycobacterium smegmatis TetR family transcriptional repressor that regulates cell growth and morphophysiology

SR Wani, AA Dubey, V Jain - FEBS letters, 2023 - Wiley Online Library
Transcriptional factors such as the TetR family of transcriptional regulators (TFTRs) are
widely found amongst bacteria, including mycobacteria, and are accountable for their …

From a hetero-to a methylotrophic lifestyle: Flash back on the engineering strategies to create synthetic methanol-user strains

C Peiro, CM Vicente, D Jallet, S Heux - Frontiers in Bioengineering …, 2022 - frontiersin.org
Engineering microorganisms to grow on alternative feedstocks is crucial not just because of
the indisputable biotechnological applications but also to deepen our understanding of …