Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The cell biology of mitochondrial membrane dynamics

M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

[HTML][HTML] GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

X Ma, Z Liu, I Ilyas, PJ Little, D Kamato… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD),
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …

Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission

Q Wang, M Zhang, G Torres, S Wu, C Ouyang, Z Xie… - Diabetes, 2017 - Am Diabetes Assoc
Metformin is a widely used antidiabetic drug that exerts cardiovascular protective effects in
patients with diabetes. How metformin protects against diabetes-related cardiovascular …

Mitochondria-associated endoplasmic reticulum membranes in cardiovascular diseases

P Gao, Z Yan, Z Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

YE Li, JR Sowers, C Hetz, J Ren - Cell death & disease, 2022 - nature.com
The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …

Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology

C Lopez-Crisosto, C Pennanen… - Nature Reviews …, 2017 - nature.com
Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

PINK1/Parkin‐mediated mitophagy promotes apelin‐13‐induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions

L He, Q Zhou, Z Huang, J Xu, H Zhou… - Journal of cellular …, 2019 - Wiley Online Library
Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the
pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin …

The role of mitochondrial fission proteins in mitochondrial dynamics in kidney disease

L Qin, S Xi - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondria have many forms and can change their shape through fusion and fission of the
outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer …

Mitochondrial-shaping proteins in cardiac health and disease–the long and the short of it!

SB Ong, SB Kalkhoran, S Hernández-Reséndiz… - … drugs and therapy, 2017 - Springer
Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …