Mitochondrial dynamics in health and disease: mechanisms and potential targets
W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
The cell biology of mitochondrial membrane dynamics
M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …
mitochondria are often considered the 'powerhouses of the cell'. However, our …
[HTML][HTML] GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD),
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …
Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission
Metformin is a widely used antidiabetic drug that exerts cardiovascular protective effects in
patients with diabetes. How metformin protects against diabetes-related cardiovascular …
patients with diabetes. How metformin protects against diabetes-related cardiovascular …
Mitochondria-associated endoplasmic reticulum membranes in cardiovascular diseases
P Gao, Z Yan, Z Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …
Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases
The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …
organelles with vital roles in the regulation of cell signaling and function. While the ER …
Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology
C Lopez-Crisosto, C Pennanen… - Nature Reviews …, 2017 - nature.com
Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …
on a sustained energy supply and adequate calcium buffering, both of which are provided …
PINK1/Parkin‐mediated mitophagy promotes apelin‐13‐induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions
L He, Q Zhou, Z Huang, J Xu, H Zhou… - Journal of cellular …, 2019 - Wiley Online Library
Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the
pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin …
pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin …
The role of mitochondrial fission proteins in mitochondrial dynamics in kidney disease
L Qin, S Xi - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondria have many forms and can change their shape through fusion and fission of the
outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer …
outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer …
Mitochondrial-shaping proteins in cardiac health and disease–the long and the short of it!
Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …
changes in mitochondrial morphology, a process which is regulated by mitochondrial …