Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

The metabolic syndrome is prevalent in developed nations and accounts for the largest
burden of non-communicable diseases worldwide. The metabolic syndrome has direct …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Molecular clocks are present in almost every cell to anticipate daily recurring and
predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions …

A majority of mammalian genes exhibit daily fluctuations in expression levels, making
circadian expression rhythms the largest known regulatory network in normal physiology …

The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms
organize metabolism by temporally separating opposing metabolic processes and by …