Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation
JA Mills, F Liu, TR Jarrett, NL Fletcher… - Biomaterials …, 2022 - pubs.rsc.org
For decades, nanomedicines have been reported as a potential means to overcome the
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …
Multimodal targeting of glioma with functionalized nanoparticles
HE Marei - Cancer Cell International, 2022 - Springer
The most common and aggressive primitive intracranial tumor of the central nervous system
is the glioma. The blood–brain barrier (BBB) has proven to be a significant obstacle to the …
is the glioma. The blood–brain barrier (BBB) has proven to be a significant obstacle to the …
Non-viral vector-mediated gene therapy for ALS: challenges and future perspectives
GR Ediriweera, L Chen, JJ Yerbury… - Molecular …, 2021 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, for which
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …
no effective treatment is yet available to either slow or terminate it. Recent advances in gene …
Antifouling polymers for nanomedicine and surfaces: recent advances
Antifouling polymers are materials that can resist nonspecific interactions with cells, proteins,
and other biomolecules. Typically, they are hydrophilic polymers with polar or charged …
and other biomolecules. Typically, they are hydrophilic polymers with polar or charged …
Engineering fluorescent gold nanoclusters using xanthate-functionalized hydrophilic polymers: toward enhanced monodispersity and stability
We introduce xanthate-functionalized poly (cyclic imino ethers) s (PCIEs), specifically poly (2-
ethyl-2-oxazoline) and poly (2-ethyl-2-oxazine) given their stealth characteristics, as an …
ethyl-2-oxazoline) and poly (2-ethyl-2-oxazine) given their stealth characteristics, as an …
Interactions of core cross-linked poly (2-oxazoline) and poly (2-oxazine) micelles with immune cells in human blood
Water-soluble poly (cyclic imino ether) s (PCIEs) have emerged as promising biocompatible
polymers for nanomedicine applications in recent years. Despite their generally accepted …
polymers for nanomedicine applications in recent years. Despite their generally accepted …
Mitigating the Effects of Persistent Antipolymer Immune Reactions in Nanomedicine: Evaluating Materials-Based Approaches Using Molecular Imaging
Poly (ethylene glycol)(PEG) is a hydrophilic polymer ubiquitously used in both medical and
nonmedical goods. Recent debate surrounding the observed stimulation of immune …
nonmedical goods. Recent debate surrounding the observed stimulation of immune …
Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption
Personalised nanomedicine is an advancing field which has developed significant
improvements for targeting therapeutics to aggressive cancer and with fewer side effects …
improvements for targeting therapeutics to aggressive cancer and with fewer side effects …
From thermogelling hydrogels toward functional bioinks: Controlled modification and cytocompatible crosslinking
Hydrogels are key components in bioink formulations to ensure printability and stability in
biofabrication. In this study, a well‐known Diels‐Alder two‐step post‐polymerization …
biofabrication. In this study, a well‐known Diels‐Alder two‐step post‐polymerization …
Overcoming barriers: clinical translation of siRNA nanomedicines
T Tieu, Y Wei, A Cifuentes‐Rius… - Advanced …, 2021 - Wiley Online Library
RNA interference has garnered new hope for many difficult to treat diseases that have been
“undruggable” using conventional small molecule drugs or monoclonal antibodies. Small …
“undruggable” using conventional small molecule drugs or monoclonal antibodies. Small …